Oxycodone therapy is contraindicated in patients with respiratory depression, acute bronchospasm, hypercarbia, hypersensitivity to oxycodone, and known or suspected ileus or gastrointestinal obstruction.
If limited information exists involving studies of allergenic cross-reactivity in opioid medications, the possibility of cross-sensitivity cannot be fully excluded. For patients with an opioid allergy, a clear description of the allergic reaction should be explored and documented adequately before considering. Patients who have a true allergic reaction to other opioid medications should avoid therapy when possible.
